ProSpec APOE3 Human,ProSpec CYT-874,ProSpec产品,ProSpec代理,ProSpec产品目录,ProSpec 细胞因子,ProSpec Cytokines,Apolipoprotein E, LDLCQ5, APO-E, LPG, AD2, Alzheimer Disease 2 , Apolipoprotein E3, APOE.
APOE3 Human
Apolipoprotein E3 Human Recombinant
CYT-874
ProSpec-APOE3 Human/CYT-874 100µg
ProSpec-APOE3 Human/CYT-874 500µg
ProSpec-APOE3 Human/CYT-874 1mg
Catalogue number
CYT-874
Synonyms
Apolipoprotein E, LDLCQ5, APO-E, LPG, AD2, Alzheimer Disease 2 , Apolipoprotein E3, APOE.
载脂蛋白 E、LDL5、APO-E、LPG、AD2、Algeimer Disase 2、载脂蛋白 E、APOE。
Introduction
Apolipoprotein E3 is a 34kDa protein component of serum chylomicrons, VLDL, and HDL particles. ApoE mediates the binding, uptake, and catabolism of these particles as a result of interactions with the ApoE receptor and LDL receptors in the liver and brain. ApoE is imperative in fatty acid homeostasis and memory formation. Polymorphisms encode 3 variants , which are differentially connected to the development of atherosclerosis and neurogenerative disorders, mainly Alzheimer’s disease.
载脂蛋白 E3 是血清乳糜微粒、VLDL 和 HDL 颗粒的 34kDa 蛋白质成分。 由于与肝脏和大脑中的 ApoE 受体和 LDL 受体相互作用，ApoE 介导这些颗粒的结合、摄取和分解代谢。 ApoE 在脂肪酸稳态和记忆形成中必不可少。 多态性编码 3 个变体，它们与动脉粥样硬化和神经生成疾病（主要是阿尔茨海默病）的发展有不同的联系。
Description
APOE3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 306 amino acids and having a molecular mass of 35.2kDa.
在大肠杆菌中产生的 APOE3 Human Recombinant 是一条单一的、非糖基化的多肽链，包含 306 个氨基酸，分子量为 35.2kDa。
APOE 在 N 端与一个 Met 和一个 6 个氨基酸的 His 标签 [M-HHHHHH] 融合，并通过专有色谱技术进行纯化。
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
sterile filtered solution supplied in 10mM MOPS, 50mM NaCl, 0.2 % CHAPS and 1mM TCEP, PH 7.5.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein . Avoid multiple freeze-thaw cycles.
如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。对于长期储存，建议添加载体蛋白。 避免多次冻融循环。
Purity
Greater than 95% as determined by -PAGE.
Amino acid sequence
MHHHHHHKVE QAVETEPEPE LRQQTEWQSG QRWELALGRF WDYLRWVQTL SEQVQEELLS SQVTQELRAL MDETMKELKA YKSELEEQLT PVAEETRARL SKELQAAQAR LGADMEDVCG RLVQYRGEVQ AMLGQSTEEL RVRLASHLRK LRKRLLRDAD DLQKRLAVYQ AGAREGAERG LSAIRERLGP LVEQGRVRAA TVGSLAGQPL QERAQAWGER LRARMEEMGS RTRDRLDEVK EQVAEVRAKL EEQAQQIRLQ AEAFQARLKS WFEPLVEDMQ RQWAGLVEKV QAAVGTSAAP VPSDNH.
Biological Activity
Immobilized rHuApoE3 binds to rMuVLDLR with EC50 less than 0.075-0.375µg/ml.
Usage
ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
