ProSpec-APOE4 Human/CYT-968,APOE3 Human

Apolipoprotein E, APO-E, Alzheimer Disease 2 , Apolipoprotein E3, LDLCQ5, LPG, AD2, APOE.

Apolipoprotein E is a chylomicron lipoprotein which is essential for the metabolism of lipoproteins and lipid transport. The APOE gene has 3 alleles, designated APOE2, APOE3, and APOE4. The APOE allelic proteins differ by only one or two amino acids, however have different biological structures and functions. APOE3 is the most common and neutral allele. The APOE4 allele is linked with an increased risk for Alzheimer’s Disease and coronary artery disease . The APOE4 protein morphology decreases the ability of APOE4 to clear beta-amyloid protein from the brain, resulting in AD progression. The APOE2 allele is linked with type III hyperlipoproteinemia, which is characterized by defects in the clearance of plasma lipoproteins, however APOE2 may have a protective effect against AD.

载脂蛋白 E 是一种乳糜微粒脂蛋白，对脂蛋白的代谢和脂质转运至关重要。 APOE基因有3个等位基因，分别命名为APOE2、APOE3和APOE4。 APOE等位基因蛋白只有一个或两个氨基酸不同，但具有不同的生物学结构和功能。 APOE3 是最常见和中性的等位基因。 APOE4 等位基因与阿尔茨海默病和冠状动脉疾病的风险增加有关。 APOE4 蛋白形态降低了 APOE4 从大脑中清除 β-淀粉样蛋白的能力，导致 AD 进展。 APOE2等位基因与III型高脂蛋白血症相关，其特征是血浆脂蛋白清除缺陷，但APOE2可能对AD具有保护作用。

Apolipoprotein E4 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing a total of 301 amino acids and having a molecular mass of 34.4kDa. The # is P02649 VAR_000652.

在大肠杆菌中产生的载脂蛋白 E4 Human Recombinant 是一条单一的、非糖基化的多肽链，总共含有 301 个氨基酸，分子量为 34.4kDa。 # 是 P02649 VAR_000652。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

Lyophilized from a sterile filtered aqueous solution containing 10mM sodium phosphate, 0.5 mM DTT, pH 7.5.

从含有 10 mM 磷酸钠、0.5 mM DTT、pH 7.5 的无菌过滤水溶液冻干。

It is recommended to reconstitute the lyophilized APOE4 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议在不低于 100µg/ml 的无菌 18M-cm H2O 中复溶冻干的 APOE4，然后可以进一步稀释成其他水溶液。

Lyophilized APOE4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution APOE4 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 APOE4 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，APOE4 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

Greater than 90% as determined by -PAGE.

GPKVE QAVETEPEPE LRQQTEWQSG QRWELALGRF WDYLRWVQTL SEQVQEELLS SQVTQELRAL MDETMKELKA YKSELEEQLT PVAEETRARL SKELQAAQAR LGADMEDVRG RLVQYRGEVQ AMLGQSTEEL RVRLASHLRK LRKRLLRDAD DLQKRLAVYQ AGAREGAERG LSAIRERLGP LVEQGRVRAA TVGSLAGQPL QERAQAWGER LRARMEEMGS RTRDRLDEVK EQVAEVRAKL EEQAQQIRLQ AEAFQARLKS WFEPLVEDMQ RQWAGLVEKV QAAVGTSAAP VPSDNH.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。