ProSpec-GDF7 Mouse/CYT-946,Growth and Differentiation factor 7 Mouse Recombinant

Growth/differentiation factor 7, GDF-7, Gdf7.

Growth Differentiation Factor-7 belongs to the BMP family of TGF-b superfamily proteins. GDF7 elicits its bioactivity via a heterodimeric receptor complex comprised of a type 1 and a type II serine/threonine kinase receptor. GDF7 signaling results in the phosphorylation and activation of Smad proteins. GDF-7 is also involved in tendon and ligament formation and repair. In addition, GDF7 regulates bone formation, mesenchymal stem cell differentiation, neuronal differentiation, and axon guidance.

生长分化因子 7 属于 TGF-b 超家族蛋白的 BMP 家族。 GDF7 通过由 1 型和 II 型丝氨酸/苏氨酸激酶受体组成的异二聚体受体复合物引发其生物活性。 GDF7 信号传导导致 Smad 蛋白的磷酸化和活化。 GDF-7 也参与肌腱和韧带的形成和修复。 此外，GDF7 调节骨形成、间充质干细胞分化、神经元分化和轴突引导。

GDF7 Mouse Recombinant produced in E.coli is a non-glycosylated disulfide linked homodimer containing 2 chains of 146 amino acids and having a molecular mass of 29.8kDa.
The GDF-7 is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 GDF7 Mouse Recombinant 是一种非糖基化的二硫键连接的同源二聚体，包含 2 条 146 个氨基酸的链，分子量为 29.8kDa。
GDF-7 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

It is recommended to reconstitute the lyophilized GDF-7 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lyophilized GDF7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GDF-7 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein .
Please prevent freeze-thaw cycles.

冻干的 GDF7 虽然在室温下可稳定保存 3 周，但应在 -18°C 以下干燥储存。 复溶后，GDF-7 应在 4°C 下储存 2-7 天，以备将来在 -18°C 以下使用。
对于长期储存，建议添加载体蛋白。
请防止冻融循环。

The ED₅₀ as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 0.5µg/ml, corresponding to a specific activity of > 2000 IU/mg.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。