ProSpec-CTLA4 Human, igG-His/CYT-985

CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, CD152, Cytotoxic T-Lymphocyte Associated Antigen-4, igG-His Tag.

CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

CTLA-4 是免疫球蛋白超家族的成员，编码一种将抑制信号传递给 T 细胞的蛋白质。 该蛋白质包含一个V结构域、一个跨膜结构域和一个胞质尾。 已经表征了编码不同同种型的替代转录剪接变体。 膜结合异构体作为通过二硫键互连的同二聚体发挥作用，而可溶异构体作为单体发挥作用。 该基因的突变与胰岛素依赖型糖尿病、格雷夫斯病、桥本甲状腺炎、乳糜泻、系统性红斑狼疮、甲状腺相关眼眶病和其他自身免疫性疾病有关。

CTLA4 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 368 amino acids and having a molecular mass of 40.8kDa .
CTLA4 is expressed with a 239 amino acid hIgG-His-tag at C-Terminus and purified by proprietary chromatographic techniques.

在 Sf9 杆状病毒细胞中产生的 CTLA4 是单条糖基化多肽链，包含 368 个氨基酸，分子量为 40.8kDa。
CTLA4 在 C 末端用 239 个氨基酸的 hIgG-His-tag 表达，并通过专有色谱技术进行纯化。

Sf9, Baculovirus cells.

Sterile filtered colorless solution.

CTLA4 protein solution contains Phosphate Buffered Saline and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein .
Avoid multiple freeze-thaw cycles.

Greater than 95% as determined by -PAGE.

ADLKAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSDL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

ProSpec 的产品仅供实验室研究使用。 该产品不得用作药物、农业或农药产品、食品添加剂或家用化学品。