ProSpec-IFI30 Human/CYT-183

IFI30, Gamma-IFN-Inducible Lysosomal Thiol Reductase, IFN Gamma-Inducible Protein 30 Preproprotein, Gamma-IFN-Inducible Protein IP-30, Legumaturain, GILT, IP30, IFI-30, MGC32056, EC 1.8.

IFNI30 inducible lysosomal thiol reductase , is a part of the GILT family. IFI30 is a lysosomal thiol reductase which at low pH is capable of decreasing protein’s disulfide bonds. IFI30 is expressed constitutively in antigen-presenting cells and induced by gamma-IFN in other cell types. Also, IFI30 plays an important role in MHC class II-restricted antigen processing. IFI30 facilitates the generation of MHC class II-restricted epitopes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds and Also facilitates MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or cross-presentation.

IFNI30 诱导型溶酶体硫醇还原酶是 GILT 家族的一部分。 IFI30 是一种溶酶体硫醇还原酶，在低 pH 值下能够减少蛋白质的二硫键。 IFI30 在抗原呈递细胞中组成型表达，并在其他细胞类型中由 γ-IFN 诱导。 此外，IFI30 在 MHC II 类限制性抗原加工中起重要作用。 IFI30 通过二硫键的内吞还原促进从含二硫键的抗原产生 MHC II 类限制性表位，并且还促进 CD8+ T 细胞或交叉呈递对含二硫键的外源性抗原的 MHC I 类限制性识别。

IFI30 Human Recombinant produced in E. coli is a single polypeptide chain containing 199 amino acids and having a molecular mass of 22.5 kDa. IFI30 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 IFI30 Human Recombinant 是单条多肽链，包含 199 个氨基酸，分子量为 22.5 kDa。 IFI30 在 N 端与 24 个氨基酸的 His-tag 融合，并通过专有色谱技术进行纯化。

E.coli.

Sterile Filtered colorless solution.

The IFI30 solution contains 20mM Tris-HCl buffer , 0.1M NaCl, 1mM DTT and 10% glycerol.

如果整个小瓶将在 2-4 周内使用，请在 4°C 下储存。 储存，在 -20°C 下冷冻更长时间。
对于长期储存，建议添加载体蛋白。
避免多次冻融循环。

Greater than 90% as determined by -PAGE.

MGSSHHHHHH SSGLVPRGSH MGSMNAPLVN VTLYYEALCG GCRAFLIREL FPTWLLVMEI LNVTLVPYGN AQEQNVSGRW EFKCQHGEEE CKFNKVEACV LDELDMELAF LTIVCMEEFE DMERSLPLCL QLYAPGLSPD TIMECAMGDR GMQLMHANAQ RTDALQPPHE YVPWVTVNGK  PLEDQTQLLT LVCQLYQGK.

ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.