ProSpec-RELM g Mouse/CYT-1035

Resistin-like gamma, RELMgamma,RELM-γ, RELM-g.

RELM-gamma is a novel member of the resistin-like molecule/found in inflammatory zone family in mice and rats. Microarray and real-time RT-PCR experiments revealed a repression of RELMgamma mRNA in nasal respiratory epithelium of cigarette smoke-exposed versus untreated rats. The analysis of the physiological tissue-specific expression revealed highest expression in hematopoietic tissues, suggesting a cytokine-like role for RELM-gamma. RELM-gamma-mRNA is detectable in bone marrow, spleen, and lung as well as in peripheral blood granulocytes. Promyelocytic HL60 cells transfected with a RELM-gamma expression plasmid have an increased proliferation rate compared to mock-transfected cells and display an altered response to retinoic acid-induced granulocytic differentiation. Taken together, these data provide the first experimental evidence that RELM-gamma is a secreted molecule with a restricted expression pattern that may play a role in promyelocytic differentiation.

RELM-γ是抵抗素样分子的新成员/发现于小鼠和大鼠的炎症区家族。 微阵列和实时 RT-PCR 实验揭示了香烟烟雾暴露与未处理大鼠的鼻呼吸道上皮细胞中 RELMgamma mRNA 的抑制。 生理组织特异性表达的分析揭示了造血组织中的最高表达，表明 RELM-γ 具有细胞因子样作用。 在骨髓、脾脏和肺以及外周血粒细胞中可检测到 RELM-γ-mRNA。 与模拟转染的细胞相比，用 RELM-γ 表达质粒转染的早幼粒细胞 HL60 细胞具有增加的增殖率，并显示出对视黄酸诱导的粒细胞分化的反应改变。 总之，这些数据提供了第一个实验证据，证明 RELM-γ 是一种具有受限表达模式的分泌分子，可能在早幼粒细胞分化中起作用。

RELM g Mouse Recombinant produced in E.Coli is a non glycosylated, homodimeric polypeptide chain containing 2 x 89 amino acids and having a total molecular mass of 18.9kDa.

The RELM is purified by proprietary chromatographic techniques.

在大肠杆菌中产生的 RELM g 小鼠重组体是一种非糖基化的同型二聚体多肽链，含有 2 x 89 个氨基酸，总分子量为 18.9kDa。

RELM 通过专有的色谱技术进行纯化。

Escherichia Coli.

Sterile Filtered White lyophilized powder.

Lyophilized from a sterile filtered solution containing 0.1 % trifluoroacetic acid .

It is recommended to reconstitute the lyophilized RELM g in sterile 18MΩ-cm H₂O at a concentration of 100µg/ml, which can then be further diluted to other aqueous solutions.建议在无菌 18MΩ-cm H2O 中以 100µg/ml 的浓度重新配制冻干的 RELM g，然后可以将其进一步稀释成其他水溶液。

Lyophilized RELM g although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution RELM g Mouse should be stored at 4°C between 2-7 days and for future use below -18°C.

For long term storage it is recommended to add a carrier protein .

Please prevent freeze-thaw cycles.

Greater than 95.0% as determined by -PAGE.

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ProSpec’s products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.