ProSpec-SCGB1A1 Rat/CYT-820

Uteroglobin, Clara cell 17 kDa protein, Clara cell phospholipid-binding protein, CCPBP, Clara cells 10 kDa secretory protein, CC10, PCB-binding protein, Secretoglobin family 1A member 1, Scgb1a1, Ugb, Utg, UG, CC16, CCSP, PCB-BP.

Uteroglobin which belongs to the Secretoglobin superfamily, is a multifunctional protein that exerts anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. Uteroglobin is involved in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. SCGB1A1 is expressed by Clara cells, the non-ciliated, non-mucous secretory cells predominant in lung bronchioles, and by other epithelia which communicate with the external environment. On top of sequestering pro-inflammatory mediators and carcinogens, Uteroglobin is implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation. SCGB1A1 gene defects are associated with a susceptibility to asthma.

子宫珠蛋白属于分泌珠蛋白超家族，是一种多功能蛋白，通过结合磷脂和前列腺素等疏水小分子发挥抗炎和抗肿瘤作用。 子宫珠蛋白参与多种功能，包括抗炎、抑制磷脂酶 A2 和螯合疏水配体。 SCGB1A1 由 Clara 细胞（主要存在于肺细支气管中的非纤毛、非粘液分泌细胞）和与外部环境通信的其他上皮细胞表达。 除了隔离促炎介质和致癌物外，子宫珠蛋白还参与抑制细胞迁移和侵袭、血小板聚集和 T 细胞分化。 SCGB1A1 基因缺陷与哮喘易感性有关。

SCGB1A1 Rat Recombinant produced in E.Coli is a homodimeric non-glycosylated polypeptide chains consisting of two 77 amino acids and having a molecular mass of 17.0kDa.

Escherichia Coli.

Sterile Filtered White lyophilized powder.

It is recommended to reconstitute the lyophilized SCGB1A1 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

建议在不低于 100µg/ml 的无菌 18MΩ-cm H2O 中复溶冻干的 SCGB1A1，然后可以进一步稀释成其他水溶液。

Greater than 97.0% as determined by:
Analysis by RP-HPLC.
Analysis by -PAGE.

SSDICPGFLQ VLEALLLGSE SNYEAALKPF NPASDLQNAG TQLKRLVDTL PQETRINIVK LTEKILTSPL CEQDLRV

Fully biologically active when compared to standard. The ED50 as determined by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cells is less than 5.0 ?g/ml, corresponding to a specific activity of >200IU/mg.

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